|DMSO inhibits platinum therapy cytotoxicity|
Interestingly a 2010 article in PlOS One showed that methyl sulfone may have clinical potential as a non-toxic agent effective against metastatic melanoma. Methyl sufone and DMSO are very very similar.
- DMSO (C2H6SO)
- Methyl sulfone, C2H6SO2
I don’t use Cisplatin, why should I be reading this: This paper points to two main issues. The first is a lack of quality in reporting experimental methods, it’s a message we should all listen to. The second is that a lack of understanding of this issue even though it had been previously reported up to twenty years ago.
We could all do with being clearer in our materials and methods sections. The use of supplementary files allows almost unrestricted descriptions of what we did. I find it exasperating that it can be impossible to find out what method someone actually used to create their NGS library or exactly how they sequenced it and how many reads they generated per sample. And it can be impossible to get a clear picture of the experimental design and replication used. George Church does methods right, we don’t need to know which tube you used (it’s only a 1.5ml Eppendorf after all), but the polymerase or the use of single- or paired-end reads is important. Lets all try a bit harder on our next papers.